Tetrahedron

The chemical reactivity of a known anti-psoriasis drug. Part 1: Further insights into the products resulting from oxidative cleavage

AM Jones, MM Lorion, T Lebl, AMZ Slawin, D Philp…

文献索引：Jones, Alan M.; Lorion, Magali M.; Lebl, Tomas; Slawin, Alexandra M.Z.; Philp, Douglas; Westwood, Nicholas J. Tetrahedron, 2010 , vol. 66, # 51 p. 9667 - 9674

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被引用次数: 3

摘要

The oxidative cleavage of the known anti-psoriasis drug 1 to give 2 has been reported previously. Due to the importance of accessing medium-sized ring containing systems via oxidative cleavage, this reaction has been revisited revealing additional information about the structure of 2. Alternative reaction products were identified when the reaction was carried out in the presence of water. The conversion of 1 to 2 has also been carried out using ...