C–H Arylation of Pyridines: High Regioselectivity as a Consequence of the Electronic Character of C–H Bonds and Heteroarene Ring

P Guo, JM Joo, S Rakshit, D Sames

文献索引：Guo, Pengfei; Joo, Jung Min; Rakshit, Souvik; Sames, Dalibor Journal of the American Chemical Society, 2011 , vol. 133, # 41 p. 16338 - 16341

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被引用次数: 73

摘要

We report a new catalytic protocol for highly selective C–H arylation of pyridines containing common and synthetically versatile electron-withdrawing substituents (NO2, CN, F and Cl). The new protocol expands the scope of catalytic azine functionalization as the excellent regioselectivity at the 3-and 4-positions well complements the existing methods for C–H arylation and Ir-catalyzed borylation, as well as classical functionalization of pyridines. ...