Tetrahedron

Synthesis of cis-3, 4-diarylpiperidines and cis-3, 4-diaryltetrahydropyrans

MY Chang, CY Lin, CY Hung

文献索引：Chang, Meng-Yang; Lin, Chun-Yu; Hung, Ching-Yi Tetrahedron, 2007 , vol. 63, # 16 p. 3312 - 3320

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被引用次数: 16

摘要

Substituted cis-3, 4-diarylpiperidines and cis-3, 4-diaryltetrahydropyrans are synthesized in modest overall yields starting from 4-aryl-1, 2, 5, 6-tetrahydropyridines and 4-aryl-1, 2, 5, 6- tetrahydropyrans via the following sequence:(1) pinacol-type ring contraction having the combination of m-chloroperoxybenzoic acid and boron trifluoride etherate,(2) Grignard addition with arylmagnesium bromide reagents and followed by boron trifluoride etherate- ...