Tetrahedron Letters

Palladium-catalyzed regiocontrolled internal heteroarylation of electron-rich olefins with heteroaryl halides

D Xu, Z Liu, W Tang, L Xu, Z Hyder, J Xiao

文献索引：Xu, Dan; Liu, Zhihua; Tang, Weijun; Xu, Lijin; Hyder, Zeynab; Xiao, Jianliang Tetrahedron Letters, 2008 , vol. 49, # 42 p. 6104 - 6107

全文：HTML全文

被引用次数: 16

摘要

A highly efficient palladium-catalyzed Heck coupling reaction of heteroaryl halides with electron-rich vinyl ether and hydroxyalkyl vinyl ethers is described. It was found that the choice of solvent, ligand, and reaction temperature had a fundamental influence on the regioselectivity and reactivity of the reaction, and the combination of Pd (OAc) 2 and DPPF in ethylene glycol led to the most effective catalytic system. Under these conditions, a variety ...