The Journal of Organic Chemistry

A Novel Synthesis of Phosphonates from Diethyl (Trichloromethyl) phosphonate

GT Lowen, MR Almond

文献索引：Lowen, Gregory T.; Almond, Merrick R. Journal of Organic Chemistry, 1994 , vol. 59, # 16 p. 4548 - 4550

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被引用次数: 14

摘要

Phosphonates are interesting complements to phosphates in terms of biological activity and have been well documented in recent literature. Unlike phosphates, the phosphonate linkage is not susceptible to hydrolysis by esterases and is chemically stable. Acyclic nucleoside phosphonates are a novel class of antiviral agents that exhibit broad-spectrum inhibition of DNA viruses (eg, adenovirus, Epstein-Barr virus, hepatitis B virus, acyclovir- ...