Abstract Enolized 1, 3-dioxane-4, 6-dione-5-carboxamides a were identified as a new class of inhibitors of secretory phospholipase A 2 from human polymorphonuclear leucocytes (h- PMN PLA 2). Among the more than 30 compounds synthesized, the most potent inhibitors (IC 50 0.6–10 μM) were found in the series of 2, 4-disubstituted phenyl analogues of a. Compound 1a was selected for evaluation of its biological profile. This substance potently ...
[Leenders, Ruben G. G.; Damen, Eric W. P.; Bijsterveld, Edward J. A.; Scheeren, Hans W.; Houba, Pieter H. J.; Van Der Meulen-Muileman, Ida H.; Boven, Epie; Haisma, Hidde J. Bioorganic and Medicinal Chemistry, 1999 , vol. 7, # 8 p. 1597 - 1610]
