Bioorganic & medicinal chemistry

Synthesis and biological evaluation of cepharadiones A and B and related dioxoaporphines

MA Elban, JC Chapuis, M Li, SM Hecht

文献索引：Elban, Mark A.; Chapuis, Jean C.; Li, Mei; Hecht, Sidney M. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 18 p. 6119 - 6125

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被引用次数: 6

摘要

Described herein is the first total synthesis and structural confirmation of cepharadione A, a naturally occurring DNA damaging agent. Also reported is the synthesis of cepharadione B, a closely related natural product, as well as the biological evaluation of both natural products. Finally, the preparation and biological evaluation of novel dioxoaporphine analogues is described.