A dramatic solvent effect during aromatic halogen-metal exchanges. Different products from lithiation of polyfluorobromobenzenes in ether and tetrahydrofuran

AJ Bridges, WC Patt, TM Stickney

文献索引：Bridges, Alexander J.; Patt, William C.; Stickney, Thomas M. Journal of Organic Chemistry, 1990 , vol. 55, # 2 p. 773 - 775

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被引用次数: 34

摘要

4+ 10% 1% 2 4 1 1 2 prepared via cyanation (CuCN) of 3 followed by acid hydrolysis,'it appeared that bromine-lithium exchange followed by carboxylation would be operationally simpler. Halogen-metal exchange is a very well-established technique for the ...