Molecules

Synthesis, bioevaluation and structural study of substituted phthalazin-1 (2H)-ones acting as antifungal agents

…, B Barboza, AE García-Cadenas, JL López-Pérez…

文献索引：Derita, Marcos; Del Olmo, Esther; Barboza, Bianca; Garcia-Cadenas, Ana Esther; Lopez-Perez, Jose Luis; Andujar, Sebastian; Enriz, Daniel; Zacchino, Susana; Feliciano, Arturo San Molecules, 2013 , vol. 18, # 3 p. 3479 - 3501

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被引用次数: 5

摘要

Abstract: Twenty-five polysubstituted phthalazinone derivatives were synthesized and tested for their antifungal activity against a panel of pathogenic and clinically important yeasts and filamentous fungi. Among them, the compound 4-(4-chlorobenzyl)-2-methylphthalazin-1 (2 H)-one (5) exhibited a remarkable antifungal activity against standardised strains of dermatophytes and Cryptococcus neoformans, as well as against some clinical isolates. A ...