Xenobiotica

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A

L Salphati

文献索引：Salphati, Laurent; Benet, Leslie Z. Xenobiotica, 1999 , vol. 29, # 2 p. 171 - 185

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被引用次数: 65

摘要

1. The sequential metabolism of digoxin (Dg3) to digoxigenin bis-digitoxoside (Dg2), digoxigenin mono-digitoxoside (Dg1) and digoxigenin (Dg0) was investigated in rat liver microsomes. 2. Kinetic studies produced results consistent with a single enzyme mechanism