Chemical Communications

Tandem ring-closing metathesis and hydrogenation towards cyclic dinucleotides

P Børsting, P Nielsen

文献索引：Borsting, Philip; Nielsen, Poul Chemical Communications, 2002 , # 18 p. 2140 - 2141

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被引用次数: 30

摘要

Conformational restriction of nucleic acid fragments has attracted a lot of attention due to important potential applications in therapeutics and diagnostics. 1,2 Thus, oligonucleotides containing nucleoside monomers with bi- and tricyclic carbohydrate moieties have demonstrated high affinity for complementary nucleic acids. 2–4 Furthermore, conformationally restricted dinucleotides mimicking tertiary structure elements 5–7 eg the anticodon loop in bacterial tRNA 7 have ...