Identification of novel L-amino acid α-ligases through hidden Markov model-based profile analysis

…, K Tabata, Y Yonetani, M Yagasaki

文献索引：Senoo, Akihiro; Tabata, Kazuhiko; Yonetani, Yoshiyuki; Yagasaki, Makoto Bioscience, Biotechnology and Biochemistry, 2010 , vol. 74, # 2 p. 415 - 418

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被引用次数: 7

摘要

l-Amino acid α-ligase (Lal), catalyzing the formation of α-dipeptides from unprotected l- amino acids in an ATP-dependent manner, is used in cost-effective fermentative production of dipeptides. We searched for novel Lals by in silico screening using Hidden Markov Model- based profile analysis, and identified five novel Lals that showed low similarity and different substrate specificity from known Lals.