Tetrahedron

Total synthesis of tryprostatins A and B

T Yamakawa, E Ideue, Y Iwaki, A Sato, H Tokuyama…

文献索引：Yamakawa, Takayuki; Ideue, Eiji; Iwaki, Yuzo; Sato, Ayumu; Tokuyama, Hidetoshi; Shimokawa, Jun; Fukuyama, Tohru Tetrahedron, 2011 , vol. 67, # 35 p. 6547 - 6560

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被引用次数: 9

摘要

Three distinct synthetic routes to the 2-prenyl tryptophan core skeleton of tryprostatins and their total syntheses are described. The strategies include a traditional gramine-mediated coupling reaction, Fürstner indole synthesis, and our radical-mediated indole synthesis from o-alkenylphenyl isocyanide. The establishment of reliable conditions for the radical- mediated construction of indoles via a low-temperature radical initiator V-70 (2, 2′-azobis ...