Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors

…, AMF Oliveira-Campos, MSJ Nascimento…

文献索引：Gupta, Sanjay; Rodrigues, Ligia M.; Esteves, Ana P.; Oliveira-Campos, Ana M.F.; Nascimento, M. Sao Jose; Nazareth; Cidade, Honorina; Neves, Marta P.; Fernandes, Eduarda; Pinto, Madalena; Cerqueira, Nuno M.F.S.A.; Bras, Natercia European Journal of Medicinal Chemistry, 2008 , vol. 43, # 4 p. 771 - 780

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被引用次数: 77

摘要

Some pyrazolo [3, 4-d] pyrimidines, structurally related with allopurinol, a well known xanthine oxidase inhibitor, clinically used in the therapy of gout, have also been reported as potent inhibitors of xanthine oxidase and the growth of several human tumour cell lines. Considering the potential interest of this family of compounds, the aim of the present study was to synthesise and provide a full chemical characterization of new N-aryl-5-amino-4- ...