2-Aryl-3, 6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists

…, M Gulianello, A Kieltyka, R Primus, R Brodbeck…

文献索引：Hodgetts, Kevin J.; Yoon, Taeyoung; Huang, Jianhua; Gulianello, Michael; Kieltyka, Andrzej; Primus, Renee; Brodbeck, Robbin; De Lombaert, Stephane; Doller, Dario Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 15 p. 2497 - 2500

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被引用次数: 14

摘要

In spite of numerous marketed treatments, anxiety and depression are psychiatric disorders which constitute a major health concern. Agents with increased efficacy or a reduced side-effects profile are actively sought by pharmaceutical companies. Corticotropin-releasing factor (CRF) is a 41-aminoacid peptide characterized as the principal mediator of the effects of stress via the hypothalamic-pituitary-adrenocortical (HPA) axis. CRF receptors are 7-transmembrane ...