Hydroxamic Acids as Potent Inhibitors of FeII and MnII E. coli Methionine Aminopeptidase: Biological Activities and X??ray Structures of Oxazole Hydroxamate– …

…, R Alves de Sousa, A Lieutaud, J Chevalier…

文献索引：Huguet, Florian; Melet, Armelle; Alves de Sousa, Rodolphe; Lieutaud, Aurelie; Chevalier, Jacqueline; Maigre, Laure; Deschamps, Patrick; Tomas, Alain; Leulliot, Nicolas; Pages, Jean-Marie; Artaud, Isabelle ChemMedChem, 2012 , vol. 7, # 6 p. 1020 - 1030

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被引用次数: 17

摘要

Abstract New series of acids and hydroxamic acids linked to five-membered heterocycles including furan, oxazole, 1, 2, 4-or 1, 3, 4-oxadiazole, and imidazole were synthesized and tested as inhibitors against the Fe II, Co II, and Mn II forms of E. coli methionine aminopeptidase (MetAP) and as antibacterial agents against wild-type and acrAB E. coli strains. 2-Aryloxazol-4-ylcarboxylic acids appeared as potent and selective inhibitors of ...