Tetrahedron

Highly enantioselective fluorination reactions of β-ketoesters and β-ketophosphonates catalyzed by chiral palladium complexes

Y Hamashima, T Suzuki, H Takano, Y Shimura…

文献索引：Hamashima, Yoshitaka; Suzuki, Toshiaki; Takano, Hisashi; Shimura, Yuta; Sodeoka, Mikiko Journal of the American Chemical Society, 2005 , vol. 127, # 29 p. 10164 - 10165

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被引用次数: 71

摘要

Using chiral palladium enolates as key intermediates, efficient catalytic enantioselective fluorination reactions of active methine compounds have been developed. These reactions can be conducted in alcoholic solvents without any precaution to exclude water and moisture, and various β-ketoesters and β-ketophosphonates were fluorinated in a highly enantioselective manner (up to 98% ee).