Tetrahedron letters

Methylamine deprotection provides increased yield of oligoribonucleotides

MP Reddy, F Farooqui, NB Hanna

文献索引：Reddy, M. P.; Farooqui, Firdous; Hanna, Naeem B. Tetrahedron Letters, 1995 , vol. 36, # 49 p. 8929 - 8932

全文：HTML全文

被引用次数: 35

摘要

Use of methylamine or methylamine/ammonium hydroxide as a cleavage and deprotection reagent for the solid phase synthesis of Oligoribonucleotides has significantly increased the yield of the full length Oligoribonucleotides as compared to the use of conventional ammonium hydroxide/ethanol.