Highly Enantioselective Hydrogenation of β??Alkyl and β??(ω??Chloroalkyl) Substituted β??Keto Esters

I Karamé, E Bellur, S Rotzoll, P Langer…

文献索引：Karame, Iyad; Bellur, Esen; Rotzoll, Sven; Langer, Peter; Fischer, Christine; Holz, Jens; Boerner, Armin Synthetic Communications, 2007 , vol. 37, # 7 p. 1067 - 1076

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被引用次数: 4

摘要

Abstract Highly enantioselective hydrogenation of β??alkyl and β??(ω??chloroalkyl) substituted β??keto esters was achieved with Ru catalysts based on chiral diphosphines in EtOH at 50° C under 50??bar initial hydrogen pressure, affording the corresponding β??hydroxy esters in> 98% ee.