Chemoenzymatic synthesis, structural study and biological activity of novel indolizidine and quinolizidine iminocyclitols

L Gómez, X Garrabou, J Joglar, J Bujons…

文献索引：Gomez, Livia; Garrabou, Xavier; Joglar, Jesus; Bujons, Jordi; Parella, Teodor; Vilaplana, Cristina; Cardona, Pere Joan; Clapes, Pere Organic and Biomolecular Chemistry, 2012 , vol. 10, # 31 p. 6309 - 6321

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被引用次数: 25

摘要

The synthesis, conformational study and inhibitory properties of diverse indolizidine and quinolizidine iminocyclitols are described. The compounds were chemo-enzymatically synthesized by two-step aldol addition and reductive amination reactions. The aldol addition of dihydroxyacetone phosphate (DHAP) to N-Cbz-piperidine carbaldehyde derivatives catalyzed by L-rhamnulose 1-phosphate aldolase from Escherichia coli provides the key ...