Steroidal Heterocycles. VII. 1 Androstano [2, 3-d] isoxazoles and Related Compounds

AJ Manson, FW Stonner, HC Neumann…

文献索引：Manson,A.J. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, # 1 p. 1 - 9

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被引用次数: 99

摘要

In a previous publication* me outlined attempts to alter the nucleophilic environment near position 3 of the steroid nucleus3 by the attachment of a pyrazole ring at the 2, 3-positions. This approach was based upon the rationalization that the cellular receptor sites would vary sufficiently to make the question of fit one of paramount importance. The success of our initial efforts in synthesizing steroidal [3, 2-c] pyrazoles with very high anabolic/androgenic ...