The Syntheses of ι-Trifluoromethyl Amino Acids. II. 1, 2 Their Microbiological Activities

HM Walborsky, M Baum…

文献索引：Walborsky et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 3637,3639

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被引用次数: 55

摘要

At first sight it would seem that the fact that we obtained smooth decarboxylation and isolated the p-hydroxy acid as the only product, was in direct contrast to Corey's mechanism. This need not be the case since it has been demonstrated previously', 6 that tri0uorocrotonic acid is attacked very readily by nucleophilic reagents: therefore as the decarboxylative elimination occurs (I-111, the hydroxyl group may be forming a loose ion pair with the ...