The atherogenic process can be characterized on the basis of predictable morphological and biochemical changes in arteries. The most outstanding biochemical change to occur in arteries during atherogenesis is the accumulation of lipids, particularly cholesterol and its esters.'Along with HMG-CoA reductase and 7a-hydroxylasey acyl-CoA: cholesterol 0- acyltransferase (ACAT) is one of the major regulators of cholesterol metabolism in cells. 2 ...
