Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity

K Moriyama, T Suzuki, K Negishi, JD Graci…

文献索引：Moriyama, Kei; Suzuki, Tetsuya; Negishi, Kazuo; Graci, Jason D.; Thompson, Corinne N.; Cameron, Craig E.; Watanabe, Masahiko Journal of Medicinal Chemistry, 2008 , vol. 51, # 1 p. 159 - 166

全文：HTML全文

被引用次数: 24

摘要

One of the possible mechanisms of antiviral action of ribavirin (1-β-d-ribofuranosyl-1, 2, 4- triazole-3-carboxamide, 1) is the accumulation of mutations in viral genomic RNA. The ambiguous incorporation of 5′-triphosphate of ribavirin (RTP, 8) by a viral RNA-dependent RNA polymerase (RdRp) is a key step of the mutation induction. We synthesized three ribavirin analogues that possess hydrophobic groups, 4-iodo-1-β-d-ribofuranosylpyrazole- ...