Tetrahedron

Enantioselective synthesis of nonphosphorus-containing phosphotyrosyl mimetics and their use in the preparation of tyrosine phosphatase inhibitory peptides

…, H Zhao, GWA Milne, L Wu, ZY Zhang, JH Voigt

文献索引：Burke Jr., Terrence R.; Yao, Zhu-Jun; Zhao, He; Milne, George W. A.; Wu, Li; Zhang, Zhong-Yin; Voigt, Johannes H. Tetrahedron, 1998 , vol. 54, # 34 p. 9981 - 9994

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被引用次数: 59

摘要

Three new L-amino acid analogues 12, 18 and 25 have been prepared in protected form suitable for incorporation into peptides by solid-phase synthesis using Fmoc protocols. These agents represent nonphosphorus-containing phosphotyrosyl (pTyr) mimetics, which utilize carboxylic groups to provide functionality normally afforded by the pTyr phosphate group. To demonstrate the utility of these analogues, the protein-tyrosine phosphatase- ...