Journal of the Chemical Society C: Organic

Acetylation and acetoxylation of 4-hydroxy-1, 4-benzothiazin-and-benzoxazin-3 (4 H)-ones (cyclic hydroxamic acids)

RT Coutts, NJ Pound

文献索引：Coutts,R.T.; Pound,N.J. Journal of the Chemical Society [Section] C: Organic, 1971 , p. 2696 - 2699

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被引用次数: 5

摘要

Treatment of 4-hydroxy-2H-1, 4-benzothiazin-3 (4H)-one (Ia) and its 6-methyl derivatives (Ie) with acetyl chloride yielded 4-acetoxy-derivatives (Ib and f); however, when acetic anhydride was the acetylating agent, 2-acetoxy-lactams (Ic and g) were obtained. In contrast, only 4- acetoxy-2H-1, 4-benzothiazin-3 (4H)-one 1, 1-dioxide (IIb) was isolated when the sulphone corresponding to (Ia) was heated with either acetyl chloride or acetic anhydride. Whereas ...