Substituted 1, 3-dihydro-2H-pyrrolo [2, 3-b] pyridin-2-ones as potential antiinflammatory agents

PC Ting, JJ Kaminski, MH Sherlock…

文献索引：Ting, Pauline C.; Kaminski, James J.; Sherlock, Margaret H.; Tom, Wing C.; Lee, Joe F.; et al. Journal of Medicinal Chemistry, 1990 , vol. 33, # 10 p. 2697 - 2706

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被引用次数: 32

摘要

A series of analogues based on the 1, 3-dihydro-2H-pyrrolo [2, 3-b] pyridin-2-one ring system have been synthesized and shown to possess oral antiinflammatory activity in both the reverse passive Arthus reaction (RPAR) pleural cavity assay in rats and in the adjuvant- induced arthritic rat model (AAR). Several members of this series additionally exhibit an inhibitory effect on the in vivo production of prostaglandin-and leukotriene-derived ...