Reported here are (i) a new synthetic approach for preparation of (ii) a new compound class, of–OH, for example, an–OH group is replaced with acetyl protecting group, protected 1, 2- dehydrocholine analogs and (iii) a new synthetic route for betaine aldehyde. The C¼C bond of 1, 2-dehydrocholine moiety can be used for molecular addition of parahydrogen producing–OH protected hyperpolarized choline by parahydrogen-induced polarization ( ...