Based on the reported anticancer activity of quinolines, a new series of 7-chloroquinoline derivatives bearing the biologically active benzenesulfonamide moiety 2–17 and 19–25 were synthesized starting with 4, 7-dichloroquinolne 1. Compound 17 was the most active compound with IC 50 value 64.41, 75.05 and 30.71 µM compared with Doxorubicin as reference drug with IC 50 values 82.53, 88.32 and 73.72 µM on breast cancer cells, skin ...
