SAR of 3, 4-dihydropyrido [3, 2-d] pyrimidone p38 inhibitors
…, CD Schwartz, CE Fitzgerald, SJ O'Keefe…
文献索引：Liu, Luping; Stelmach, John E.; Natarajan, Swaminathan R.; Chen, Meng-Hsin; Singh, Suresh B.; Schwartz, Cheryl D.; Fitzgerald, Catherine E.; O'Keefe, Stephen J.; Zaller, Dennis M.; Schmatz, Dennis M.; Doherty, James B. Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3979 - 3982
Development for a class of potent 3, 4-dihydropyrido (3, 2-d) pyrimidone inhibitors of p38a MAP kinase is described. Modification of N-1 aryl and C-6 arylsulfide in 3, 4-dihydropyrido (3, 2-d) pyrimidone analogues for the interaction with the hydrophobic pockets in p38 active site is also discussed.
