Design, synthesis, and SAR analysis of cytotoxic sinapyl alcohol derivatives

…, HB Li, JX Gong, LL Sun, XM Wu, H Bai, BT Fan…

文献索引：Zou, Hong Bin; Dong, Sheng Yi; Zhou, Chang Xin; Hu, Li Hong; Wu, Yi Hang; Li, Hai Bo; Gong, Jing Xu; Sun, Lian Li; Wu, Xiu Mei; Bai, Hua; Fan, Bo Tao; Hao, Xiao Jiang; Stoeckigt, Joachim; Zhao, Yu Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 6 p. 2060 - 2071

全文：HTML全文

被引用次数: 19

摘要

Five series totalling 51 of sinapyl alcohol derivatives were designed and synthesized. Their cytotoxicity analyses were performed on six human tumor cell lines such as PC-3, CNE, KB, A549, BEL-7404, and HeLa. Certain sinapyl alcohol derivatives showed significant cytotoxic activities. Compound 14d exhibited especially potent cytotoxicity against the BEL-7404 cell line with an IC50 value of 0.7 μM, which showed more cytotoxic activity than the positive ...