Tetrahedron letters

Design, synthesis, and validation of rigid linkers for bioactive peptides

Y Monguchi, J Vagner, HL Handl, U Jana, LJ Begay…

文献索引：Monguchi, Yasunari; Vagner, Josef; Handl, Heather L.; Jana, Umasish; Begay, Lucinda J.; Hruby, Victor J.; Gillies, Robert J.; Mash, Eugene A. Tetrahedron Letters, 2005 , vol. 46, # 44 p. 7589 - 7592

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被引用次数: 11

摘要

Rigid linkers of variable length were synthesized and used to connect two NDP-α-MSH ligands. The linkers were incorporated by solid-phase synthesis. Biological evaluations indicate that there is virtually no effect of these linkers on ligand binding to the human melanocortin 4 receptor.