Hydrolysis of toxic natural glucosides catalyzed by cyclodextrin dicyanohydrins

J Bjerre, EH Nielsen, M Bols

文献索引：Bjerre, Jeannette; Nielsen, Erik Holm; Bols, Mikael European Journal of Organic Chemistry, 2008 , # 4 p. 745 - 752

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被引用次数: 21

摘要

Abstract The hydrolysis of toxic 7-hydroxycoumarin glucosides and other aryl and alkyl glucosides, catalyzed by modified α-and β-cyclodextrin dicyanohydrins, was investigated using different UV, redox, or HPAEC detection assays. The catalyzed reactions all followed Michaelis–Menten kinetics, and an impressive rate increase of up to 7569 (k cat/k uncat) was found for the hydroxycoumarin glucoside substrate 4-MUGP. Good and moderate ...