Synthesis and structure-activity relationship of 4-(1, 3-benzothiazol-2-yl)-thiophene-2-sulfonamides as cyclin-dependent kinase 5 (cdk5)/p25 inhibitors

J Malmström, J Viklund, C Slivo, A Costa…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 18 p. 5919 - 5923

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被引用次数: 14

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Medicinal Chemistry, CNSP iMed ... Furthermore, compound 4a also exhibited a desirable c log P (2.4) and good experimentally determined physico-chemical and permeability properties (solubility 24 μM; Caco-2 permeability 32 μcm/ ...