1, 2-Benzothiazines. 6. 3-Carbamoyl-4-hydroxy-2H-1, 2-benzothiazine 1, 1-dioxides as antiinflammatory agents

H Zinnes, NA Lindo, JC Sircar…

文献索引：Zinnes,H. et al. Journal of Medicinal Chemistry, 1973 , vol. 16, p. 44 - 48

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被引用次数: 31

摘要

A variety of new 3-carbamoyl-4-hydroxy-2H-1, 2-benzothiazine 1, 1-dioxides of structure I1 was prepared and evaluated an antiinflammatory agents. Three synthetic methods were employed. Method A, consisting of base-catalyzed carbamoylation of ketone I by isocyanates, and method B, involving aminolysis of P-keto ester 111, are modifications of previously described processes. In the completely new method C, the enamine IV, derived ...