Nonpeptide renin inhibitors employing a novel 3-aza (or oxa)-2, 4-dialkyl glutaric acid moiety as a P2/P3 amide bond replacement

…, HD Kleinert, HH Stein, JJ Plattner…

文献索引：Baker, William R.; Fung, Anthony K. L.; Kleinert, Hollis D.; Stein, Herman H.; Plattner, Jacob J.; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 10 p. 1722 - 1734

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被引用次数: 25

摘要

Modulation of the renin-angiotensin-aldosterone system (RAAS) has proven to be a viable approach for treating various cardiovascular disorders (Figure 1). The effector hormone of the RAAS cascade, angiotensin I1 (ANG 11), regulates blood pressure and fluid balance. The major pharmacological effects of ANG I1 are vasoconstriction and stimulation of the adrenal cortex to release aldosterone, a hormone that causes sodium retention, thereby ...