Synthetic Communications

Improved synthetic approach to tenatoprazole

L Dai, D Fan, X Wang, Y Chen

文献索引：Dai, Liyan; Fan, Dongbo; Wang, Xiaozhong; Chen, Yingqi Synthetic Communications, 2008 , vol. 38, # 4 p. 576 - 582

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被引用次数: 6

摘要

Abstract An improved synthetic approach to tenatoprazole 1 is described. It started from 2, 3, 5??trimethyl??4??nitropyridine??N??oxide 2 with acetic anhydride via rearrangement and hydrolysis to give 3, Chlorination with SOCl2 yielded 2??chloromethyl??3, 5??dimethyl??4?? nitropyridine hydrochloride 4, then 4 condensed with 2??mercapto??5??methoxy imidazole [4, 5?? b] pyridine 5 to give 5??methoxy??2??[(4??nitro??3, 5??dimethyl??2??pyridinyl) methylthio] ...