New melatonin (MT 1/MT 2) ligands: Design and synthesis of (8, 9-dihydro-7H-furo [3, 2-f] chromen-1-yl) derivatives

E Landagaray, M Ettaoussi, V Leclerc, B Traoré…

文献索引：Landagaray, Elodie; Ettaoussi, Mohamed; Leclerc, Veronique; Traore, Balla; Perez, Valerie; Nosjean, Olivier; Boutin, Jean A.; Caignard, Daniel-Henri; Delagrange, Philippe; Berthelot, Pascal; Yous, Said Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 3 p. 986 - 996

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被引用次数: 8

摘要

Abstract Herein we describe the synthesis of novel tricyclic analogues issued from the rigidification of the methoxy group of the benzofuranic analogue of melatonin as MT 1 and MT 2 ligands. Most of the synthesized compounds displayed high binding affinities at MT 1 and MT 2 receptors subtypes. Compound 6b (MT 1, K i= 0.07 nM; MT 2, K i= 0.08 nM) exhibited with the vinyl 6c and allyl 6d the most interesting derivatives of this series. ...