Tetrahedron letters

An efficient ZrCl 4 catalyzed one-pot solvent free protocol for the synthesis of 4-substituted coumarins

GVM Sharma, JJ Reddy, PS Lakshmi, PR Krishna

文献索引：Sharma; Janardhan Reddy; Sree Lakshmi; Radha Krishna Tetrahedron Letters, 2005 , vol. 46, # 36 p. 6119 - 6121

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被引用次数: 101

摘要

A versatile and efficient route to 4-substituted coumarins via a Pechmann reaction using ZrCl4 as the catalyst (10mol%) is described. This method provides several advantages over alternative procedures such as mild, solvent-free conditions at ambient temperature, and direct isolation of the products in high yields.