Indoline and piperazine containing derivatives as a novel class of mixed D 2/D 4 receptor antagonists. Part 1: identification and structure–activity relationships

H Zhao, A Thurkauf, X He, K Hodgetts, X Zhang…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 21 p. 3105 - 3109

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被引用次数: 19

摘要

... Bioorganic & Medicinal Chemistry Letters. ... Screening of a chemical library uncovered 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 showing high affinity binding for D 4 (1.6 nM), relatively modest binding for D 2 (690 nM) and significant affinity for ...