3-(1H-Tetrazol-5-yl)-4 (3H)-quinazolinone sodium salt (MDL 427): a new antiallergic agent

NP Peet, LE Baugh, S Sunder, JE Lewis…

文献索引：Peet, Norton P.; Baugh, Larry E.; Sunder, Shyam; Lewis, Jon E.; Matthews, Emily H.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2403 - 2409

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被引用次数: 63

摘要

Syntheses for 3-(1H-tetrazol-5-yl)-4 (3H)-quinazolinone sodium salt monohydrate (9; MDL 427) and the related formamido compound, 2-(formylamino)-N-VI-tetrazol-5-ylbenzamide (lo), are described. Both compounds are active in the rat passive cutaneous anaphylaxis and passive peritoneal anaphylaxis tests. A 94: 6 equilibrium mixture of 9 and ionized 10, respectively, forms in aqueous buffer systems at a pH-dependent rate. In addition, ...