Abstract Several dialkylaminoethyl benzo [b] thiophene-3-carboxylates, N-(2- dialkylaminoethyl) benzo [b] thiophene-3-carboxamides, 2-dialkylaminoethyl benzo [b] thiophene-3-carbamates, and substituted ureas with benzo [b] thiophene moiety, were prepared and tested for local anesthetic, anticholinergic, and antihistaminic activities. Several of the compounds showed significant activity.