Liposomal formulation of retinoids designed for enzyme triggered release

…, AK Subramanian, A Arouri, TL Andresen…

文献索引：Pedersen, Palle J.; Adolph, Sidsel K.; Subramanian, Arun K.; Arouri, Ahmad; Andresen, Thomas L.; Mouritsen, Ole G.; Madsen, Robert; Madsen, Mogens W.; Peters, Guenther H.; Clausen, Mads H. Journal of Medicinal Chemistry, 2010 , vol. 53, # 9 p. 3782 - 3792

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被引用次数: 43

摘要

The design of retinoid phospholipid prodrugs is described based on molecular dynamics simulations and cytotoxicity studies of synthetic retinoid esters. The prodrugs are degradable by secretory phospholipase A2 IIA and have potential in liposomal drug delivery targeting tumors. We have synthesized four different retinoid phospholipid prodrugs and shown that they form particles in the liposome size region with average diameters of 94− 118 nm. ...