New carbamoylpiperidines as human platelet aggregation inhibitors

Z Guo, X Zheng, W Thompson, M Dugdale…

文献索引：Guo, Zhengming; Zheng, Xiaozhang; Thompson, Walter; Dugdale, Marion; Gollamudi, Ram Bioorganic and Medicinal Chemistry, 2000 , vol. 8, # 5 p. 1041 - 1058

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被引用次数: 14

摘要

A series of 3-carbamoylpiperidines (nipecotamides) are designed, synthesized and tested for their inhibitory action against adenosine diphosphate (ADP)-induced aggregation of human platelets. A structure–activity analysis of the bis (nipecotamido) aralkane type showed that a substituent on the piperidine ring should preferably be an amide and that the electronegativity of the carbonyl oxygen and the orientation of the amide group affected ...