Tetrahedron Letters

One-pot N-alkylation/Heck approach to substituted indoles

ML Weinrich, HP Beck

文献索引：Weinrich, Melissa L.; Beck, Hilary P. Tetrahedron Letters, 2009 , vol. 50, # 50 p. 6968 - 6972

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被引用次数: 19

摘要

Due to the prevalence of indole functionality in several biologically active molecules, many research efforts are focused on developing novel general, mild, and efficient methods for the regioselective preparation of substituted indoles from readily available starting materials. 1 The intramolecular Heck reaction has been widely used for the synthesis of substituted indoles. 2 In addition, indoles have been prepared utilizing one-pot cascade reactions. 3 For example, the palladium- ...