Novel benzimidazoles as ligands for the strychnine-insensitive N-methyl-d-aspartate-linked glycine receptor

…, G Lallement, I Pernot-Marino, C Luu-Duc…

文献索引：Louvet, P.; Lallement, G.; Pernot-Marino, I.; Luu-Duc, C.; Blanchet, G. European Journal of Medicinal Chemistry, 1993 , vol. 28, # 1 p. 71 - 75

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被引用次数: 15

摘要

Abstract Two new benzimidazole derivatives were synthesized and evaluated for their ability to inhibit the binding at the strychnine-insensitive N-methyl-d-aspartate (NMDA)-linked glycine receptor. The most potent one, the 4, 6-dichlorobenzimidazole-2-carboxylic acid 6, was found to have submicromolar affinity for this receptor. The result of its functional test suggests that it acts as an antagonist of the NMDA receptor complex. Thus, this class of ...