Synthesis of some new pyridazin??3??one derivatives and their utility in heterocyclic synthesis

MM El??Mobayed, AM Hussein…

文献索引：El-Mobayed, Medhat M.; Hussein, Ahmed M.; Mohlhel, Wafia M. Journal of Heterocyclic Chemistry, 2010 , vol. 47, # 3 p. 534 - 537

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被引用次数: 7

摘要

A large number of pyridazinone derivatives were reported to exhibit insecticidal [1–5], herbicidal [2, 6], antiallergenic [7], antihypertensive [8], analgesic [9], anti-inflammatory [10], and bacteriocidal activities [11]. This prompted us to synthesize a new series of heterocyclic pyridazinone derivatives through the reaction of 4-(p-bromophenyl) or 4-(p-methylphenyl)-4- oxo-2-butenoic acid 1a, b [12] with benzylamine in dry benzene and yielded the addition ...