Quinolone–benzylpiperidine derivatives as novel acetylcholinesterase inhibitor and antioxidant hybrids for Alzheimer Disease

…, L Ismaïli, I Tomassoli, A Iutzeler, B Refouvelet

文献索引：Pudlo, Marc; Luzet, Vincent; Ismaili, Lhassane; Tomassoli, Isabelle; Iutzeler, Anne; Refouvelet, Bernard Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 8 p. 2496 - 2507

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被引用次数: 17

摘要

Abstract Design, synthesis and evaluation of new acetylcholinesterase inhibitors by combining quinolinecarboxamide to a benzylpiperidine moiety are described. Then, a series of hybrids have been developed by introducing radical scavengers. Molecular modeling was performed and structure activity relationships are discussed. Among the series, most potent compounds show effective AchE inhibitions, high selectivities over butyrylcholinesterase ...