The design, synthesis and calcimimetic properties of various cyclic sulfonamides and sulfamates are described. The latter were prepared from the corresponding o- alkenylarenesulfonamides via copper-or rhodium-catalyzed intramolecular aziridination. The size of the cyclic sulfonamide rings as well as the position of the crucial (R)- naphthylethylamine substituent significantly affected calcimimetic activity. The most active ...
