Abstract Primary thioamides are prepared in excellent yield from the corresponding nitrile by treatment with ammonium sulfide in methanol, at room temperature for electron-deficient aromatic nitriles or under microwave irradiation at 80 C or 130 C in 15-30 minutes for other aromatic and aliphatic nitriles. This procedure avoids the use of gaseous H 2 S under high pressure, proceeds in the absence of base and provides thioamides usually without the ...
